Editor’s Choice – Volume 17 No 4
This issue of Dialogues in Clinical Neuroscience looks at the complex topic of emotions.The subject is examined from a variety of different perspectives, to aid our understanding of emotions and their involvement in the etiology, diagnosis, and treatment of psychiatric diseases.
Emotions are widely altered in many psychiatric disorders, such as manic and depressive states or in schizophrenia. Alan Anticevic et al focus on emotional dysregulation in schizophrenia and major depressive disorder, looking at dysfunctions of hedonic and anticipatory behavior in reward-seeking. The unique disturbances in each disorder involve dissociable neural systems and interactions between affect and cognition.
The consequences of dysfunctions in emotion processing on social functioning, as well as the direct effects of psychotropic drugs such as antidepressants on emotions (independently of depression) are analyzed. Catherine Harmer and Abbie Pringle describe the modulation of emotional processing by antidepressants in healthy volunteers, and highlight the potential usefulness of human models in testing the efficacy of new treatments and identifying the individual patients or subgroups of patients who could best benefit from them.
Finally, Mark Leary emphasizes the important role of rejection as a threat to acceptance and belonging in humans, and examines seven emotions such as hurt feelings, jealousy, shame, guilt, and loneliness, in terms of their evolutionary functions and the brain regions involved.
December 2015 - Vol 17 - No. 4
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