onpharmacological treatments for anxiety
dis-ordersalthough of varied orientationsare
unequallyrepresented in the literature. The
bulk of the research isdevoted to behavior therapy (BT) and, more
recently, tocognitive therapy (CT) methods. Both
CT and BT tech-niques are used in combination by the
vast majority ofclinicians and researchers under the
label of cognitivebehavior therapy (CBT). Relaxation
methods have beenused as the main technique in anxiety
disorders or stud-ied as a control condition in some
randomized controlledtrials (RCTs). Some relaxation
techniques, such as Ostsapplied relaxation,1-3 are
in fact made of several cognitiveand behavioral techniques. Psychoanalytic
(or psycho-dynamic) therapies, hypnotherapy, Rogerian
nondirec-tive therapy, supportive therapy
(ST), and psychologicaldebriefing for posttraumatic stress
disorder (PTSD) havebeen evaluated in RCTs and meta-analyses.Transcranialneurostimulation and psychosurgery techniques havebeen studied in obsessive-compulsive
disorders (OCDs).Some preliminary data exist for sympathectomy inereutophobia. Hence an evidence-based
review of allthese nonpharmacological methods is
possible.Panic disorder and agoraphobiaCBT in panic disorder and agoraphobiaPanic disorder and agoraphobia are
treated using twobasic strategies: exposure (in
imagination and in vivo orinteroceptive exposure) and cognitive
restructuring.3 0 5C l i n i c a l r e s e a r c hNonpharmacological treatments for anxiety disordersJean Cottraux, MD, PhDKeywords: anxiety disorder; meta-analysis; controlled trial; cognitive-behavior therapy;
psychological therapy; debriefing; psychosurgeryAuthor affiliations: Jean
Cottraux, MD, PhD, Anxiety Disorder Unit, HôpitalNeurologique, Lyon, FranceAddress for correspondence: Jean Cottraux, MD, PhD, Anxiety DisorderUnit, Hôpital Neurologique, 59
boulevard Pinel, 69394, Lyon, France(e-mail: cottraux@univ-lyon1.fr)An evidence-based review of nonpharmacological
treat-ments for anxiety disorders is presented.
The vast major-ity of the controlled research is
devoted to cognitivebehavior therapy (CBT) and shows
its efficiency andeffectiveness in all the Diagnostic
and Statistical Manualof Mental Disorders, Fourth Edition
(DSM-IV) anxietydisorders in meta-analyses. Relaxation,
psychoanalytictherapies, Rogerian nondirective
therapy, hypnotherapy,and supportive therapy were examined
in a few con-trolled studies, which preclude any
definite conclusionabout their effectiveness in specific
phobias, agorapho-bia, panic disorder, obsessive-compulsive
disorder (OCD),and posttraumatic stress disorder
(PTSD). CBT was clearlybetter than psychoanalytic therapy
in generalized anx-iety disorder (GAD) and performance
anxiety. Psycho-logical debriefing for PTSD appeared
detrimental to thepatients in one high-quality meta-analysis.
Uncontrolledstudies of psychosurgery techniques
for intractable OCDdemonstrated a limited success and
detrimental sideeffects. The same was true for sympathectomy
in ereu-tophobia. Transcranial neurostimulation for OCD isunder preliminary study. The theoretical
and practicalproblems of CBT dissemination are
discussed.Dialogues Clin Neurosci.
2002;4:305-319.N