C o n t e n t s1 4 7EditorialJean-Paul Macher, Marc-Antoine CrocqIn this issueManfred AckenheilState of the ArtVarious forms of depression Franco Benazzi (Italy)Basic ResearchChanges in the immune system in depression and dementia:causal or coincidental effects?Brian E. Leonard (Ireland), Ayemu Myint (The Netherlands) Future prospects in depression researchPaul E. Holtzheimer, Charles B. Nemeroff (USA) Pharmacological AspectsTreatments in depression Fabrice Duval (France), Barry D. Lebowitz (USA), Jean-Paul Macher (France)Clinical ResearchRating scales in depression: limitations and pitfalls Per Bech (Denmark) Depression and sleep: pathophysiology and treatmentMichael E. Thase (USA)Somatic symptoms in depressionHans-Peter Kapfhammer (Austria) Nonpharmacological, somatic treatments of depression:electroconvulsive therapy and novel brain stimulation modalitiesRenana Eitan, Bernard Lerer (Israel) Depression and associated physical diseases and symptomsGuy M. Goodwin (UK) PosterUsing imaging to target the prefrontal cortex for transcranial magnetic stimulation studies in treatment-resistant depression Kevin Johnson, Dave Ramsey, Frank A. Kozel, Daryl E. Bohning, BerryAnderson, Ziad Nahas, Harold A. Sackeim, Mark S. George (USA)ISSUE COORDINATED BY: Manfred ACKENHEIL