C o n t e n t sEditorialJean-Paul MacherIn this issueBarry D. Lebowitz, Rajesh ParikhState of the artPsychiatric manifestations of neurologic disease:where are we headed? Constantin G. Lyketsos, Nicholas Kozauer, Peter V. Rabins (USA)Translational researchNeuropsychiatric manifestations of depression in multiple sclerosis:neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression Michele L. Pucak, Katherine A. L. Carroll, Douglas A. Kerr,Adam I. Kaplin (USA) Frontal-subcortical circuitry and behavior Raphael M. Bonelli, Jeffrey L. Cummings (USA) Clinical researchFrontotemporal dementia to Alzheimer's diseaseMaria Caterina Silveri (Italy)Tourettes syndrome: clinical features, pathophysiology,and therapeutic approaches Norbert Müller (Germany) Visual hallucinatory syndromes: past, present, and future Dominic ffytche (UK)Neuropsychiatry of Huntington's disease Adam Rosenblatt (USA)Neuropsychiatric manifestations in CADASIL Hugues Chabriat, Marie-Germaine Bousser (France)PosterHostile interactions between body and self Peter Brugger (Switzerland)Free paperQuality of life in schizophrenic patients Julio Bobes, Maria Paz Garcia-Portilla, Maria Teresa Bascaran,Pilar Alejandra Saiz, Manuel Bousoño (Spain)ISSUE COORDINATED BY: Barry Lebowitz, Rajesh Parikh