C o n t e n t sEditorialJean-Paul MacherIn this issueJean-Paul Macher, Margret HoeheState of the artHistorical and cultural aspects of man’s relationship with addictive drugs Marc-Antoine Crocq (France)Opioids, dopamine, stress, and the addictions Mary Jeanne Kreek (USA)Translational researchNeural basis of reward and craving—a homeostatic point of view Martin P. Paulus (USA) Cocaine and amphetamine-like psychostimulants:neurocircuitry and glutamate neuroplasticity Peter W. Kalivas (USA) Clinical researchOutpatient Long-term Intensive Therapy for Alcoholics (OLITA):a successful biopsychosocial approach to the treatment of alcoholismHenning Krampe, Sabina Stawicki, Margret R. Hoehe,Hannelore Ehrenreich (Germany)Cannabinoids in health and disease Natalya M. Kogan, Raphael Mechoulam (Israel) Pharmacological aspectsTherapeutic options and challenges for substances of abuse Tracie J. Gardner, Thomas R. Kosten (USA)Pharmacogenetic aspects of addictive behaviors Nadia S. Hejazi (USA)Pharmacologic treatments for opioid dependence:detoxification and maintenance options Herbert D. Kleber (USA)PosterIndividual variation in response to µ opiate receptor challenge—past,present, and future: a “personal” history of investigation Margret R. Hoehe (Germany)ISSUE COORDINATED BY: Jean-Paul Macher, Margret Hoehe
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