Bipolar Disorders

Bipolar Disorders

June 1999 – Vol 1 – No. 1


Dear Colleagues,

As you are well aware, psychiatry is a rapidly changing discipline. Progress has been facilitated by the introduction of new techniques, from brain imaging to molecular biology, and the development of new research methods. Evidence of this swift evolution can be seen in the increasing body of knowledge confronting us. Knowledge is not static, and we are continually having to revise our beliefs, question old verities, and improve our skills. Previous generations of psychiatrists have bequeathed us excellent clinical descriptions of psychiatric disorders, but this precious legacy needs constantly to be reinterpreted in the light of new neuroscientific findings. Psychiatry must therefore show flexibility and be prepared to incorporate new ideas and new facts. In order to contribute to this process, we decided to create a new journal—Dialogues in Clinical Neuroscience— with the aim of providing an interface between clinical psychiatry and basic and applied neuroscience. Each issue of this new journal will be devoted to a particular topic and will summarize the latest developments in that area.

This project has been made possible by the generous support of the Servier Research Group, and we are particularly indebted to its President, Dr Jacques Servier, for his guidance and decisive assistance.

We are committed to maintaining the quality and scientific level of each issue of Dialogues in Clinical Neuroscience and will put much effort into providing articles with state-of-the-art information.

The following topics will be discussed in 1999:

  • Bipolar Disorders
  • Transnosological Approach
  • Depression in the Elderly
  • Posttraumatic Stress Disorder

All interested scientists and clinicians are welcome to submit manuscripts for publication. Although each issue will address a specific topic, free contributions, including non–topic-related material, may be published in the “Free Papers” section of the journal. All contributions to Dialogues in Clinical Neuroscience will be reviewed by members of the Editorial Board and submitted to expert consultants for peer review. Instructions for authors are provided in the journal.

The first issue is devoted to Bipolar Disorder. Regardless of whether this disorder is narrowly or broadly defined (Bipolar I or II), it raises still unanswered questions concerning diagnosis, etiology, relevant biological markers, and optimum treatment. We hope that the following pages will convince you that Dialogues in Clinical Neuroscience is a valuable approach to contemporary psychiatry.We look forward to receiving your reactions and comments.

Sincerely yours,

Jean-Paul MACHER, MD / Marc-Antoine CROCQ, MD

Pharmacological aspects

Are all antidepressants alike?
Pierre Schulz, MD

Basic research

Molecular linkage studies of bipolar disorder
Wade H. Berrettini, MD, PhD

Biology of bipolar disorder

This is a comprehensive review of biological abnormalites observed in bipolar/unipolar mood disorder. We do not ignore that conflicting results may be found in the literature, but attempted, nevertheless, to summarize the currents trends.
Fabrice Duval, MD

Clinical research

Anticonvulsant drugs in bipolar disorder
Heinz Grunze, MD, PhD; Sandra Schlösser, MA; Benedikt Amann, MD; Jörg Walden, MD, PhD

State of the art

Bipolar disorder
Frederick K. Goodwin, MD; S. Nassir Ghaemi, MD