December 2011 – Vol 13 – No. 4


Dear Colleagues,

Anxiety is a psychological state which occurs as a reaction to a situation, which can be either a particular event, or be inherent to the individual state of health of the subject. Anxiety can be accompanied by physical feelings of discomfort. The types of events that can lead to anxiety are very varied, involving not only personal feelings such as disappointment, bereavement, and jealousy, but also events in the person’s professional or social life, or intercurrent problems. This anxiety appears in many different clinical pictures of which it forms a part, but can also develop on its own, forming the the structure of various types of anxiety disorders (neuroses, panic attacks, obsessive-compulsive disorders, etc). The problems posed by the symptomatology of anxiety are thus large in number, and create a need for reflection on various levels: signs and symptoms, nosographic organization, precipitating factors, neurobiology of anxious states, imaging, experimental models, therapeutic implications… In past issues of our journal we have already addressed certain aspects of anxiety and anxious states; in the present issue, we wished to provide an update of knowledge in this area. To this end we invited some brilliant authors to contribute, and Marc-Antoine Crocq and Deborah Morris-Rosendahl agreed to coordinate the issue: I would like to thank them all. In addition, I am pleased to inform you that the Dialogues in Clinical NeuroscienceWeb site——has been redesigned, and in the coming months we will be adding extra content. I would also like to take this seasonal opportunity to send my very best wishes for an excellent 2012 to all our authors and readers.

Sincerely yours,
Jean-Paul Macher, MD

In This issue

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Marc-Antoine Crocq, Deborah Morris-Rosendahl

State of the art

A lifespan view of anxiety disorders
Eric J. Lenze; Julie Loebach Wetherell (USA)

Clinical research

A review of obsessive-compulsive disorder in children and adolescents
Bernard Boileau, MD, CSPQ, FRCP(C)

Cognitive behavioral therapy in anxiety disorders: current state of the evidence
Christian Otte (Germany)

Pharmacological aspects

Pharmacotherapy of anxiety disorders: a critical review
Nastassja Koen; Dan J. Stein (South Africa)

Pharmacotherapy for anxiety disorders in children and adolescents
Ian Kodish (USA)

Translational research

Neuroimaging in anxiety disorders
Kathrin Holzschneider; Christoph Mulert (Germany)

NMDA receptors and fear extinction: implications for cognitive behavioral therapy
Michael Davis (USA)

Neurobiology of panic and pH chemosensation in the brain
John A. Wemmie (USA)

Experimental panic provocation in healthy man—a translational role in anti-panic drug development?
Michael Kellner (Germany)

Animal models of anxiety disorders in rats and mice: some conceptual issues
Thierry Steimer (Switzerland)