September 2014 – Vol 16 – No. 3

Editor’s Comment

Epigenetics, the post-transcriptional modification of gene expression, is the link between the environment and the genome, between nurture and nature. Consequently, familiarity with the basics of epigenetics is an intellectual requirement for any student of behavior. This issue of Dialogues in Clinical Neuroscience provides those basics, albeit in a context that convincingly conveys the impressive explanatory power of this new field for the etiopathogenesis and treatment of behavioral disorders.

In this issue

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David R. Rubinow, Deborah Morris-Rosendahl

Guest editorial

Epigenetic advances in clinical neuroscience
Ted Abel; Shane Poplawski (USA)

State of the art

Epigenetic signaling in psychiatric disorders: stress and depression
Rosemary C. Bagot; Benoit Labonté; Catherine J. Peña; Eric J. Nestler (USA)

Translational research

Lifetime stress experience: transgenerational epigenetics and germ cell programming
Tracy L. Bale (USA)

Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms
Jessica L. Bolton; Staci D. Bilbo (USA)

Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Christoph Anacker; Kieran J. O’Donnell; Michael J. Meaney (Canada)

Epigenetics, microRNA, and addiction
Paul J. Kenny (USA)

New approaches to manipulating the epigenome
Jeremy J. Day (USA)

Role of DNA methylation and the DNA methyltransferases in learning and memory
Michael J. Morris; Lisa M. Monteggia (USA)

The epigenetic dimension of Alzheimer’s disease: causal, consequence, or curiosity?
Mark J. Millan (France)

Clinical research

Epigenetic alterations in depression and antidepressant treatment
Andreas Menke; Elisabeth B. Binder (Germany,USA)

Epigenetic mechanisms in schizophrenia
Schahram Akbarian (USA)

Pharmacological aspects

DNA methylation and demethylation as targets for antipsychotic therapy
Alessandro Guidotti; Dennis R. Grayson (USA)

Brief report

Increased DNA methylation in the suicide brain
Fatemeh Haghighi; Yurong Xin; Benjamin Chanrion; Anne H. O’Donnell; Yongchao Ge; Andrew J. Dwork; Victoria Arango; J. John Mann (USA)