Drug Discovery and Proof of Concept

Drug Discovery and Proof of Concept

September 2006 – Vol 8 – No. 3

State of the art

Expression profiling of drug response – from genes to pathways
Ralf Herwig, PhD; Hans Lehrach, PhD

Pharmacological aspects

New directions for drug discovery
Michael Spedding, PhD

Contributions of molecular biology to antipsychotic drug discovery: promises fulfilled or unfulfilled?
Bryan L. Roth, MD, PhD

Membrane transporter proteins: a challenge for CNS drug development
François Girardin, MD

Experimental animal models for the simulation of depression and anxiety
Eberhard Fuchs , PhD; Gabriele Flügge, PhD

Clinical research

The role of serendipity in drug discovery
Thomas A. Ban, MD, FRCP(C)

Surrogate outcomes in neurology, psychiatry, and psychopharmacology
Luc Staner, MD

Free paper

Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia
Barbara K. Lipska, PhD