Addictive Substances

Addictive Substances

December 2007 – Vol 9 – No. 4

State of the art

Historical and cultural aspects of man’s relationship with addictive drugs
Marc-Antoine Crocq, MD

Opioids, dopamine, stress, and the addictions
Mary Jeanne Kreek, MD

Translational research

Neural basis of reward and craving – a homeostatic point of view
Martin P. Paulus, MD

Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity
Peter W. Kalivas, PhD

Clinical research

Outpatient Long-term Intensive Therapy for Alcoholics (OLITA): a successful biopsychosocial approach to the treatment of alcoholism
Henning Krampe, PhD; Sabina Stawicki, PhD; Margret R. Hoehe, MD, PhD; Hannelore Ehrenreich, MD, DVM

Cannabinoids in health and disease
Natalya M. Kogan, MSc; Raphael Mechoulam, PhD

Pharmacological aspects

Therapeutic options and challenges for substances of abuse
Tracie J. Gardner, PhD; Thomas R. Kosten, MD

Pharmacogenetic aspects of addictive behaviors
Nadia S. Hejazi, MD

Pharmacologic treatments for opioid dependence: detoxification and maintenance options
Herbert D. Kleber, MD


Individual variation in response to µ opiate receptor challenge-past, present, and future: a “personal” history of investigation
Margret R. Hoehe, MD, PhD